Job Details


Company name
Pfizer Inc

Pearl River, NY

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Recent advances in functional genomics technologies have led to unprecedented opportunities to deepen our understanding of disease biology, screen for new drug targets, and validate candidate targets arising from genetic association and other studies. As integral part of Pfizer Worldwide Research and Development our Functional Genomics group works to establish and apply experimental tools including screens for examining gene function, in order to bring the best targets into the Oncology Research Unit's portfolio and deepen our knowledge of targets under development.

We are seeking a highly motivated and pro-active cancer biologist or immunologist, with expertise in flow cytometry and gene modulation technologies, to contribute to the success of the Functional Genomics laboratory in Pearl River, NY. This is an exciting opportunity to apply cutting-edge methods and contribute with our team to the target portfolio of one of the world's leading developers of novel therapeutics.


* Independent, careful planning, execution, trouble-shooting, data analysis and summary of day- to multi-week-long experiments to test the functional consequences of genetic variants and pharmacologic agents in cell-based model systems, using co-culture systems and cell engineering methods that include lenti-/retroviral transduction and CRISPR-based gene editing technologies.

* Perform cutting-edge genomic and phenotypic CRISPR-based screens to identify new targets in immuno-oncology using advanced murine and human cell culture and transplantation systems.

* Develop and evaluate new approaches and pro-actively introduce improvements to the offerings of the Functional Genomics group.

* Work and communicate closely with other Pearl River colleagues and support interaction with our Oncology Research Unit partner sites in San Diego (La Jolla) and the Bay Area (South San Francisco).

* Present research results and discuss methods at weekly/monthly group meetings.



* Recent Ph.D. degree in immunology, cancer cell biology, or related field with substantial experience in multi-color flow cytometry required. Experience in cell sorting, functional genomic screens, and CRISPR-based gene editing or RNA interference technologies of advantage.

* 1-2 years of laboratory experience and continuous scientific curiosity in an industrial or academic setting, preferably in an immunology or cancer immunobiology group.

* Demonstrated expertise with antibiotic-free isolation, culture, and genetic manipulation of primary immune cells for advanced assays including mixed-cell

in vitro

systems and multifactorial readouts, e.g., phenotypic changes, proliferation, activation, target cell killing and production of soluble factors. Proficiency in a variety of molecular biology methods, including cloning, expression analysis, and next-generation DNA/RNA sequencing.

* Track record of substantial contributions to successful research projects. Experience with

in vivo

transplantation systems, liquid handling, and/or high content imaging a plus.

* Ability to effectively and positively interact and collaborate with other scientists, both within the group and together with other groups; excellent communication and interpersonal skills essential.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Additional Offer Details:

Grade: 8

Eligible for Employee Referral Award

Company info

Pfizer Inc
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Company Profile
Good health is vital to all of us, and finding sustainable solutions to the most pressing health care challenges of our world cannot wait. That's why we at Pfizer are committed to applying science and our global resources to improve health and well-being at every stage of life. We strive to provide access to safe, effective and affordable medicines and related health care services to the people who need them.

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