The check list below helps you even if you are not an organized person:
Pre-vacation priorities: You have to fix your priorities. Determine what is important to be done. Starting from a month before you go on vacation list out what you want to complete by your departure date. Also list out what can wait till you return from holidays.
Advance notice: You make your team understand what they are expected to do during your absence. Weeks ahead of your departure, hold a meeting of your colleagues to alert them of your vacation plan. Let them know what is on their plate.
Keep your inboxes organized: It will be a great help for your colleagues if you leave them well kept files. People should know what you are doing and whom they should contact in your absence. The process of your going off should be streamlined.
The boss: Let your staff know who is the boss in your absence. It should be clear who would be handling the project. Your team, your clients and other employees should know who is in charge.
Decide who can contact you: You should designate a person who can contact you and in what circumstances. Make it clear that the person checking your emails should know only to forward them.
Return agenda: Decide dates of meetings on your return and set post-vacation goals. Understand what would be on after your return.
Take your mind off from office: You are essential for your office and at the same time you do need time off. The office doesn't fall apart if you aren't there for a couple of weeks. Keep that in mind and enjoy your vacation and come back rejuvenated.